Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection

Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection

Tumor progression locus 2 (Tpl2) is a serine-threonine kinase known to promote inflammation in response to various pathogen-associated molecular patterns (PAMPs), inflammatory cytokines and G-protein-coupled receptors and consequently aids in host resistance to pathogens. We have recently shown that...

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Bibliographic Details
Main Authors: Krishna Latha, Katelyn F. Jamison, Wendy T. Watford
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
Tpl2
MAP3K8
influenza
interferons
inflammatory monocytes
neutrophils
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.738490/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.738490/full

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