Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers

The Gram-negative opportunistic pathogen Pseudomonas aeruginosa causes severe nosocomial infections. It uses quorum sensing (QS) to regulate and coordinate population-wide group behaviours in the infection process like concerted secretion of virulence factors. One very important signalling network i...

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Bibliographic Details
Main Authors: Christian Schütz, Martin Empting
Format: Article
Language:English
Published: Beilstein-Institut 2018-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
PQS
Online Access:https://doi.org/10.3762/bjoc.14.241