Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner

Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner

<p>Abstract</p> <p>Background</p> <p>We have investigated a simple strategy for enhancing transgene expression specificity by leveraging genetic silencer elements. The approach serves to restrict transgene expression to a tissue of interest - the nervous system in the e...

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Bibliographic Details
Main Authors: Xie Xiayang, Mathias Jonathan R, Smith Marie-Ange, Walker Steven L, Teng Yong, Distel Martin, Köster Reinhard W, Sirotkin Howard I, Saxena Meera T, Mumm Jeff S
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Biology
Subjects:
zebrafish
transgenesis
enhancer trap
NRSE/RE1
NRSF/REST
Gal4/UAS
neuron
Online Access:http://www.biomedcentral.com/1741-7007/10/93

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http://www.biomedcentral.com/1741-7007/10/93

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