A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo

A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates in vivo

Abstract The development of safe and practical strategies to prevent weakening of bone tissue is vital, yet attempts to achieve this have been hindered by a lack of understanding of the short‐term (days‐weeks) physiology of bone collagen turnover. To address this, we have developed a method to quant...

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Bibliographic Details
Main Authors: Rita Civil, Matthew S. Brook, Kirsty J. Elliott‐Sale, Lívia Santos, Ian Varley, Sanna Lensu, Heikki Kainulainen, Lauren G. Koch, Steven L. Britton, Daniel J. Wilkinson, Kenneth Smith, Craig Sale, Philip J. Atherton
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Physiological Reports
Subjects:
bone turnover
collagen synthesis
deuterium oxide
GC‐pyrolysis‐IRMS
stable isotopes
Online Access:https://doi.org/10.14814/phy2.14799

Internet

https://doi.org/10.14814/phy2.14799

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