Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Abstract Background The blood brain barrier (BBB) is the bottleneck of brain-targeted drug development. Due to their physico-chemical properties, nanoparticles (NP) can cross the BBB and accumulate in different areas of the central nervous system (CNS), thus are potential tools to carry drugs and tr...

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Bibliographic Details
Main Authors: Paulo Emílio Corrêa Leite, Mariana Rodrigues Pereira, Georgina Harris, David Pamies, Lisia Maria Gobbo dos Santos, José Mauro Granjeiro, Helena T. Hogberg, Thomas Hartung, Lena Smirnova
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Particle and Fibre Toxicology
Subjects:
Nanoparticle
Drug delivery
CNS
iPSC-derived BrainSpheres
3D LUHMES
Online Access:http://link.springer.com/article/10.1186/s12989-019-0307-3

Internet

http://link.springer.com/article/10.1186/s12989-019-0307-3

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