Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain

Background: Cerebral ischemic events, comprising of excitotoxicity, reactive oxygen production, and inflammation, adversely impact the metabolic-redox circuit in highly active neuronal metabolic profile which maintains energy-dependent brain activities. Therefore, we investigated neuro-regenerative...

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Bibliographic Details
Main Authors: Hon-Kan Yip, Navneet Kumar Dubey, Kun-Chen Lin, Pei-Hsun Sung, John Y. Chiang, Yi-Ching Chu, Chi-Ruei Huang, Yi-Ling Chen, Yue-Hua Deng, Hsin-Chung Cheng, Win-Ping Deng
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221003784