Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting

Abstract Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a high level in platelets and their progenitors, where it plays a central role in platelet functions, hemosta...

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Bibliographic Details
Main Authors: Jiansong Huang, Xia Li, Xiaofeng Shi, Mark Zhu, Jinghan Wang, Shujuan Huang, Xin Huang, Huafeng Wang, Ling Li, Huan Deng, Yulan Zhou, Jianhua Mao, Zhangbiao Long, Zhixin Ma, Wenle Ye, Jiajia Pan, Xiaodong Xi, Jie Jin
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Hematology & Oncology
Subjects:
Integrin αIIbβ3
Signal transduction
Talin
Kindlin
Transmembrane proteins
Therapeutic targeting
Online Access:http://link.springer.com/article/10.1186/s13045-019-0709-6

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http://link.springer.com/article/10.1186/s13045-019-0709-6

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