Overexpression of brain-derived neurotrophic factor in the hippocampus protects against post-stroke depression

Overexpression of brain-derived neurotrophic factor in the hippocampus protects against post-stroke depression

Post-stroke depression is associated with reduced expression of brain-derived neurotrophic factor (BDNF). In this study, we evaluated whether BDNF overexpression affects depression-like behavior in a rat model of post-stroke depression. The middle cerebral artery was occluded to produce a model of f...

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Bibliographic Details
Main Authors: Hao-hao Chen, Ning Zhang, Wei-yun Li, Ma-rong Fang, Hui Zhang, Yuan-shu Fang, Ming-xing Ding, Xiao-yan Fu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; brain injury; brain-derived neurotrophic factor; lentivirus; post-stroke depression; depression-like behavior; hippocampus; cerebral ischemia; sucrose solution consumption; open field test; chronic unpredictable mild stress; western blot assay; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=9;spage=1427;epage=1432;aulast=Chen

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=9;spage=1427;epage=1432;aulast=Chen

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