Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug

Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug

The formation and aggregation of amyloid-β-peptide (Aβ) into soluble and insoluble species represent the pathological hallmarks of Alzheimer’s disease (AD). Over the last few years, however, soluble Aβ (sAβ) prevailed over fibrillar Aβ (fAβ) as determinant of neurotoxicity. One of the main therapeut...

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Bibliographic Details
Main Authors: Emanuela Mhillaj, Massimiliano Papi, Fabiola Paciello, Andrea Silvestrini, Rolando Rolesi, Valentina Palmieri, Giordano Perini, Anna Rita Fetoni, Luigia Trabace, Cesare Mancuso
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Alzheimer’s disease
amyloid-β-peptide
bilirubin
carbon monoxide
cyclooxygenase
heme oxygenase
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.561179/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.561179/full

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