FBXW7 in Cancer: What Has Been Unraveled Thus Far?

FBXW7 in Cancer: What Has Been Unraveled Thus Far?

The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene <i>FBXW7</i> is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system (UPS) thus regulating cellular...

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Bibliographic Details
Main Authors: Bethsebie Lalduhsaki Sailo, Kishore Banik, Sosmitha Girisa, Devivasha Bordoloi, Lu Fan, Clarissa Esmeralda Halim, Hong Wang, Alan Prem Kumar, Dali Zheng, Xinliang Mao, Gautam Sethi, Ajaikumar Bahulayan Kunnumakkara
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
FBXW7
SCF complex
tumor suppressor
mutations
cancer
chemoresistance
chemosensitization
Online Access:https://www.mdpi.com/2072-6694/11/2/246

Internet

https://www.mdpi.com/2072-6694/11/2/246

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