Pharmacodynamics of ceftazidime plus tobramycin combination dosage regimens against hypermutable Pseudomonas aeruginosa isolates at simulated epithelial lining fluid concentrations in a dynamic in vitro infection model

Pharmacodynamics of ceftazidime plus tobramycin combination dosage regimens against hypermutable Pseudomonas aeruginosa isolates at simulated epithelial lining fluid concentrations in a dynamic in vitro infection model

ABSTRACT: Objectives: Hypermutable Pseudomonas aeruginosa strains are a major challenge in cystic fibrosis. We investigated bacterial killing and resistance emergence for approved ceftazidime and tobramycin regimens, alone and in combination. Methods: Pseudomonas aeruginosa PAOΔmutS and six hypermu...

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Bibliographic Details
Main Authors: Jessica R. Tait, Hajira Bilal, Tae Hwan Kim, Abigail Oh, Anton Y. Peleg, John D. Boyce, Antonio Oliver, Phillip J. Bergen, Roger L. Nation, Cornelia B. Landersdorfer
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Pharmacokinetics
Pharmacodynamics
Optimised dosing
Antibiotic combination
Dynamic in vitro infection model
Mathematical modelling
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716521001211

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http://www.sciencedirect.com/science/article/pii/S2213716521001211

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