Pre-clinical development of a recombinant, replication-competent adenovirus serotype 4 vector vaccine expressing HIV-1 envelope 1086 clade C.

Pre-clinical development of a recombinant, replication-competent adenovirus serotype 4 vector vaccine expressing HIV-1 envelope 1086 clade C.

There is a well-acknowledged need for an effective AIDS vaccine that protects against HIV-1 infection or limits in vivo viral replication. The objective of these studies is to develop a replication-competent, vaccine vector based on the adenovirus serotype 4 (Ad4) virus expressing HIV-1 envelope (En...

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Bibliographic Details
Main Authors: Jeff Alexander, Jason Mendy, Lo Vang, Jenny B Avanzini, Fermin Garduno, Darly J Manayani, Glenn Ishioka, Peggy Farness, Li-Hua Ping, Ronald Swanstrom, Robert Parks, Hua-Xin Liao, Barton F Haynes, David C Montefiori, Celia LaBranche, Jonathan Smith, Marc Gurwith, Tim Mayall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3849430?pdf=render

Internet

http://europepmc.org/articles/PMC3849430?pdf=render

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