Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer

Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer

Abstract Background Because patient-derived xenografts (PDXs) are grown in immunodeficient mouse strains, PDXs are regarded as lacking an immune microenvironment. However, whether patients’ immune cells co-exist in PDXs remains uncharacterized. Methods We cultured small pieces of lung PDX tissue in...

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Bibliographic Details
Main Authors: Xingxiang Pu, Ran Zhang, Li Wang, Yungchang Chen, Yi Xu, Apar Pataer, Ismail M. Meraz, Xiaoshan Zhang, Shuhong Wu, Lin Wu, Dan Su, Weimin Mao, John V. Heymach, Jack A. Roth, Stephen G. Swisher, Bingliang Fang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Translational Medicine
Subjects:
Lung cancer
Patient-derived xenografts (PDX)
Tumor models
Tumor-infiltrating lymphocytes
Immunotherapy
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s12967-018-1704-3

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http://link.springer.com/article/10.1186/s12967-018-1704-3

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