Antipsychotic Drug Trifluoperazine Suppresses Colorectal Cancer by Inducing G0/G1 Arrest and Apoptosis

Antipsychotic Drug Trifluoperazine Suppresses Colorectal Cancer by Inducing G0/G1 Arrest and Apoptosis

Repurposing existing drugs for cancer treatment is an effective strategy. An approved antipsychotic drug, trifluoperazine (TFP), has been reported to have potential anticancer effects against several cancer types. Here, we investigated the effect and molecular mechanism of TFP in colorectal cancer (...

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Bibliographic Details
Main Authors: Yong Xia, Chengsen Jia, Qiang Xue, Jinrui Jiang, Yao Xie, Ranran Wang, Zhiqiang Ran, Fuyan Xu, Yiwen Zhang, Tinghong Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
trifluoperazine hydrochloride
colorectal cancer
cell cycle arrest
apoptosis
programmed death-1 ligand 1 (PD-L1)
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01029/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01029/full

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