Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

The attenuation of protein synthesis via the phosphorylation of eIF2α is a major stress response of all eukaryotic cells. The growth-arrest- and DNA-damage-induced transcript 34 (GADD34) bound to the serine/threonine protein phosphatase 1 (PP1) is the necessary eIF2α phosphatase complex that returns...

Full description

Bibliographic Details
Main Authors: Meng S. Choy, Permeen Yusoff, Irene C. Lee, Jocelyn C. Newton, Catherine W. Goh, Rebecca Page, Shirish Shenolikar, Wolfgang Peti
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715005793

Internet

http://www.sciencedirect.com/science/article/pii/S2211124715005793

Similar Items