Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA

Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA

Summary: Notch is activated globally in pancreatic progenitors; however, for progenitors to differentiate into endocrine cells, they must escape Notch activation to express Neurogenin-3. Here, we find that the transcription factor nuclear factor I/A (NFIA) promotes endocrine development by regulatin...

Full description

Bibliographic Details
Main Authors: Marissa A. Scavuzzo, Jolanta Chmielowiec, Diane Yang, Katrina Wamble, Lesley S. Chaboub, Lita Duraine, Burak Tepe, Stacey M. Glasgow, Benjamin R. Arenkiel, Christel Brou, Benjamin Deneen, Malgorzata Borowiak
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718318692

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718318692

Similar Items