Spinal Hyper-Excitability and Altered Muscle Structure Contribute to Muscle Hypertonia in Newborns After Antenatal Hypoxia-Ischemia in a Rabbit Cerebral Palsy Model

Spinal Hyper-Excitability and Altered Muscle Structure Contribute to Muscle Hypertonia in Newborns After Antenatal Hypoxia-Ischemia in a Rabbit Cerebral Palsy Model

Rabbit kits after global antenatal hypoxic-ischemic injury exhibit motor deficits similar to humans with cerebral palsy. We tested several mechanisms previously implicated in spinal hyper-excitability after perinatal brain injury that may explain muscle hypertonia in newborns. Stiffness of hind limb...

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Bibliographic Details
Main Authors: Sylvia Synowiec, Jing Lu, Lei Yu, Ivan Goussakov, Richard Lieber, Alexander Drobyshevsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Neurology
Subjects:
cerebral palsy
spinal excitability
muscle mechanical property
motoneurons
perinatal brain injury
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.01183/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2018.01183/full

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