HIV-1 Nef-induced lncRNA AK006025 regulates CXCL9/10/11 cluster gene expression in astrocytes through interaction with CBP/P300

HIV-1 Nef-induced lncRNA AK006025 regulates CXCL9/10/11 cluster gene expression in astrocytes through interaction with CBP/P300

Abstract Background HIV-associated neurocognitive disorder (HAND) is a neurodegenerative disease associated with persistent neuroinflammation and subsequent neuron damage. Pro-inflammatory factors and neurotoxins from activated astrocytes by HIV-1 itself and its encoded proteins, including the negat...

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Bibliographic Details
Main Authors: Feng Zhou, Xiaomei Liu, Dongjiao Zuo, Min Xue, Lin Gao, Ying Yang, Jing Wang, Liping Niu, Qianwen Cao, Xiangyang Li, Hui Hua, Bo Zhang, Minmin Hu, Dianshuai Gao, Kuiyang Zheng, Yoshihiro Izumiya, Renxian Tang
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Neuroinflammation
Subjects:
HIV-associated neurocognitive disorder
HIV-1
lncRNAs
Astrocytes
Nef
CBP/P300
Online Access:http://link.springer.com/article/10.1186/s12974-018-1343-x

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http://link.springer.com/article/10.1186/s12974-018-1343-x

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