Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

Summary: Chronic pain presents a major unmet clinical problem. The development of more effective treatments is hindered by our limited understanding of the neuronal circuits underlying sensory perception. Here, we show that parvalbumin (PV)-expressing dorsal horn interneurons modulate the passage of...

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Bibliographic Details
Main Authors: Kieran A. Boyle, Mark A. Gradwell, Toshiharu Yasaka, Allen C. Dickie, Erika Polgár, Robert P. Ganley, Desmond P.H. Orr, Masahiko Watanabe, Victoria E. Abraira, Emily D. Kuehn, Amanda L. Zimmerman, David D. Ginty, Robert J. Callister, Brett A. Graham, David I. Hughes
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471930806X

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http://www.sciencedirect.com/science/article/pii/S221112471930806X

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