Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury

Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury

Metformin, a first-line drug for type-2 diabetes, has been shown to improve locomotor recovery after spinal cord injury. However, there are studies reporting no beneficial effect. Recently, we found that high dose of metformin (200 mg/kg, intraperitoneal) and acute phase administration (immediately...

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Bibliographic Details
Main Authors: Wen-Ye Song, Han Ding, Tiffany Dunn, Jun-Ling Gao, Javier Allende Labastida, Caitlin Schlagal, Guang-Zhi Ning, Shi-Qing Feng, Ping Wu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
inflammation; locomotor function; metformin; microglia; mortality; neuroprotection; spinal cord injury; subacute administration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=11;spage=2234;epage=2242;aulast=Song

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=11;spage=2234;epage=2242;aulast=Song

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