A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates

A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates

Abstract We present a non-human primate mycobacterial growth inhibition assay (MGIA) using in vitro blood or cell co-culture with the aim of refining and expediting early tuberculosis vaccine testing. We have taken steps to optimise the assay using cryopreserved peripheral blood mononuclear cells, t...

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Bibliographic Details
Main Authors: Rachel Tanner, Andrew D. White, Charelle Boot, Claudia C. Sombroek, Matthew K. O’Shea, Daniel Wright, Emily Hoogkamer, Julia Bitencourt, Stephanie A. Harris, Charlotte Sarfas, Rachel Wittenberg, Iman Satti, Helen A. Fletcher, Frank A. W. Verreck, Sally A. Sharpe, Helen McShane
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-020-00263-7

Internet

https://doi.org/10.1038/s41541-020-00263-7

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