Improving Payload Capacity and Anti-Tumor Efficacy of Mesenchymal Stem Cells Using TAT Peptide Functionalized Polymeric Nanoparticles

Improving Payload Capacity and Anti-Tumor Efficacy of Mesenchymal Stem Cells Using TAT Peptide Functionalized Polymeric Nanoparticles

Mesenchymal stem cells (MSCs) accumulate specifically in both primary tumors and metastases following systemic administration. However, the poor payload capacity of MSCs limits their use in small molecule drug delivery. To improve drug payload in MSCs, we explored polymeric nanoparticles that were f...

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Bibliographic Details
Main Authors: Gopikrishna Moku, Buddhadev Layek, Lana Trautman, Samuel Putnam, Jayanth Panyam, Swayam Prabha
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
mesenchymal stem cells (MSCs)
TAT peptide
PLGA
paclitaxel
nano-engineered MSCs
orthotopic lung tumor model
Online Access:https://www.mdpi.com/2072-6694/11/4/491

Internet

https://www.mdpi.com/2072-6694/11/4/491

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