Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer’s disease

Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder, affecting millions of people worldwide. Although dysfunction of multiple neurotransmitter systems including cholinergic, glutamatergic and GABAergic systems has been associated with AD progression...

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Bibliographic Details
Main Authors: Yue Wang, Zheng Wu, Yu-Ting Bai, Gang-Yi Wu, Gong Chen
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
GAD67
Haploinsufficiency
Amyloid beta
Astrocytic GABA
Tonic inhibition
Online Access:http://link.springer.com/article/10.1186/s13024-017-0213-9

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http://link.springer.com/article/10.1186/s13024-017-0213-9

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