Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering—A Critical Risk for Chromothripsis

Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering—A Critical Risk for Chromothripsis

For precision cancer radiotherapy, high linear energy transfer (LET) particle irradiation offers a substantial advantage over photon-based irradiation. In contrast to the sparse deposition of low-density energy by χ- or γ-rays, particle irradiation causes focal DNA damage through high-density energy...

Full description

Bibliographic Details
Main Authors: Antonio Pantelias, Demetre Zafiropoulos, Roberto Cherubini, Lucia Sarchiapone, Viviana De Nadal, Gabriel E. Pantelias, Alexandros G. Georgakilas, Georgia I. Terzoudi
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
high-LET particle radiation
protons
α-particles
C-ions
premature chromosome condensation (PCC)
PCC assay
Online Access:https://www.mdpi.com/2072-6694/12/9/2336

Internet

https://www.mdpi.com/2072-6694/12/9/2336

Similar Items