Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.

Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.

Hepatospecific deletion of PTEN results in constitutive activation of Akt and increased lipogenesis. In mice, the addition of a high fat diet (HFD) downregulates lipogenesis. The aim of this study was to determine the effects of a HFD on hepatocellular damage induced by deletion of PTEN.12 Week old...

Full description

Bibliographic Details
Main Authors: Colin T Shearn, Kelly E Mercer, David J Orlicky, Leah Hennings, Rebecca L Smathers-McCullough, Bangyan L Stiles, Martin J J Ronis, Dennis R Petersen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4018288?pdf=render

Internet

http://europepmc.org/articles/PMC4018288?pdf=render

Similar Items