Deep brain stimulation of the subthalamic nucleus preferentially alters the translational profile of striatopallidal neurons in an animal model of Parkinson’s disease

Deep brain stimulation of the subthalamic nucleus preferentially alters the translational profile of striatopallidal neurons in an animal model of Parkinson’s disease

Deep brain stimulation targeting the subthalamic nucleus (STN-DBS) is an effective surgical treatment for the motor symptoms of Parkinson’s disease (PD), the precise neuronal mechanisms of which both at molecular and network levels remain a topic of debate. Here we employ two transgenic mouse lines,...

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Bibliographic Details
Main Authors: Iman eKamali Sarvestani, Naomi P Visanji, Meaghan C Creed, Zahra eShams Shoaei, José eNobrega, Clement eHamani, Lili-Naz eHazrati
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Deep Brain Stimulation
Subthalamic Nucleus
Parkinson’s disease
Striatal medium spiny neurons
Translational profile
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00221/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00221/full

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