Heterologous expression and biochemical characterization of an α1,2-mannosidase encoded by the Candida albicans MNS1 gene

Heterologous expression and biochemical characterization of an α1,2-mannosidase encoded by the Candida albicans MNS1 gene

Protein glycosylation pathways, commonly found in fungal pathogens, offer an attractive new area of study for the discovery of antifungal targets. In particular, these post-translational modifications are required for virulence and proper cell wall assembly in Candida albicans, an opportunistic huma...

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Bibliographic Details
Main Authors: Héctor M Mora-Montes, Everardo López-Romero, Samuel Zinker, Patricia Ponce-Noyola, Arturo Flores-Carreón
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2008-11-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
1,2-mannosidase
heterologous expression
glycosyl hydrolase family 47
Candida albicans
polyclonal antibodies
N-glycosylation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000700016

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000700016

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