Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in <i>Xenopus Laevis</i> Oocytes

Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in <i>Xenopus Laevis</i> Oocytes

Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown. Here we show that: oligomycin sensitive ATP synthase activity is significa...

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Bibliographic Details
Main Authors: James Cobley, Anna Noble, Rachel Bessell, Matthew Guille, Holger Husi
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Antioxidants
Subjects:
mitochondria
thiol
redox signaling
atp synthase
oocyte
xenopus laevis
click chemistry
Online Access:https://www.mdpi.com/2076-3921/9/3/215

Internet

https://www.mdpi.com/2076-3921/9/3/215

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