Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation

Docosahexaenoic acid inhibits cancer cell growth via p27Kip1, CDK2, ERK1/ERK2, and retinoblastoma phosphorylation

Docosahexaenoic acid (DHA), a PUFA of the n-3 family, inhibited the growth of FM3A mouse mammary cancer cells by arresting their progression from the late-G1 to the S phase of the cell cycle. DHA upregulated p27Kip1 levels by inhibiting phosphorylation of mitogen-activated protein (MAP) kinases, i.e...

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Bibliographic Details
Main Authors: Naim A. Khan, Kazuhiro Nishimura, Virginie Aires, Tomoko Yamashita, David Oaxaca-Castillo, Keiko Kashiwagi, Kazuei Igarashi
Format: Article
Language:English
Published: Elsevier 2006-10-01
Series:Journal of Lipid Research
Subjects:
fatty acids
cell cycle
cyclin-dependent kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520434182

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http://www.sciencedirect.com/science/article/pii/S0022227520434182

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