Development of therapeutic-grade small interfering RNAs by chemical engineering

Recent successes in clinical trials have provided important proof of concept that small interfering RNAs indeed constitute a new promising class of therapeutics. Although great efforts are still needed to ensure efficient means of delivery in vivo, the siRNA molecule itself has been successfully eng...

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Bibliographic Details
Main Authors: Jesper Bertram Bramsen, Jørgen eKjems
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Genetics
Subjects:
LNA
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00154/full