The Influence of Genetic Stability on Aspergillus fumigatus Virulence and Azole Resistance

The Influence of Genetic Stability on Aspergillus fumigatus Virulence and Azole Resistance

Genetic stability is extremely important for the survival of every living organism, and a very complex set of genes has evolved to cope with DNA repair upon DNA damage. Here, we investigated the Aspergillus fumigatus AtmA (Ataxia-telangiectasia mutated, ATM) and AtrA kinases, and how they impact vir...

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Bibliographic Details
Main Authors: Thaila Fernanda dos Reis, Lilian Pereira Silva, Patrícia Alves de Castro, Pollyne Borborema Almeida de Lima, Rafaela Andrade do Carmo, Marjorie Mendes Marini, José Franco da Silveira, Beatriz Henriques Ferreira, Fernando Rodrigues, Iran Malavazi, Gustavo H. Goldman
Format: Article
Language:English
Published: Oxford University Press 2018-01-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Aspergillus fumigatus
ATM
ATR
azoles
DNA damage
Galleria mellonela
genetic instability
PFGE
virulence
voriconazole
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300265

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http://g3journal.org/lookup/doi/10.1534/g3.117.300265

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