Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy

Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy

Histone DeACetylases (HDACs) are enzymes that remove acetyl groups from histones and other proteins, regulating the expression of target genes. Pharmacological inhibition of these enzymes re-shapes chromatin acetylation status, confusing boundaries between transcriptionally active and quiescent chro...

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Bibliographic Details
Main Authors: Gloria Manzotti, Alessia Ciarrocchi, Valentina Sancisi
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
epigenetic drugs
histone modifications
BET protein
HDAC
combination therapy
cancer
Online Access:http://www.mdpi.com/2072-6694/11/3/304

Internet

http://www.mdpi.com/2072-6694/11/3/304

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