Endothelial Barrier Integrity Is Disrupted In Vitro by Heme and by Serum From Sickle Cell Disease Patients

Endothelial Barrier Integrity Is Disrupted In Vitro by Heme and by Serum From Sickle Cell Disease Patients

Free extracellular heme has been shown to activate several compartments of innate immunity, acting as a danger-associated molecular pattern (DAMP) in hemolytic diseases. Although localized endothelial barrier (EB) disruption is an important part of inflammation that allows circulating leukocytes to...

Full description

Bibliographic Details
Main Authors: Vanessa Araujo Gomes Santaterra, Maiara Marx Luz Fiusa, Bidossessi Wilfried Hounkpe, Francine Chenou, Wouitchekpo Vincent Tonasse, Loredana Nilkenes Gomes da Costa, Diego Garcia-Weber, Igor de Farias Domingos, Franciele de Lima, Ivanio Teixeira Borba-Junior, Aderson da Silva Araújo, Antonio Roberto Lucena-Araújo, Marcos André Cavalcante Bezerra, Magnun Nueldo Nunes dos Santos, Fernando Ferreira Costa, Jaime Millán, Erich Vinicius De Paula
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
endothelial barrier
heme
sickle cell disease
electric cell-substrate impedance sensing
danger-associated molecular pattern
hemopexin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.535147/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.535147/full

Similar Items