The association of genomic lesions and PD-1/PD-L1 expression in resected triple-negative breast cancers

The association of genomic lesions and PD-1/PD-L1 expression in resected triple-negative breast cancers

Abstract Background Elevated PD-L1 expression on tumor cells, a context associated with an adaptive immune response, has been linked to the total burden of copy number variants (CNVs) in aneuploid tumors, to microsatellite instability (MSI), and to specific genomic driver lesions, including loss of...

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Bibliographic Details
Main Authors: Michael T. Barrett, Elizabeth Lenkiewicz, Smriti Malasi, Anamika Basu, Jennifer Holmes Yearley, Lakshmanan Annamalai, Ann E. McCullough, Heidi E. Kosiorek, Pooja Narang, Melissa A. Wilson Sayres, Meixuan Chen, Karen S. Anderson, Barbara A. Pockaj
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Breast Cancer Research
Subjects:
PD-1
PD-L1
IHC
Flow sorting
Copy number
Somatic mutations
Online Access:http://link.springer.com/article/10.1186/s13058-018-1004-0

Internet

http://link.springer.com/article/10.1186/s13058-018-1004-0

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