HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.

HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.

Broadly neutralizing antibody (bnAb) induction is a high priority for effective HIV-1 vaccination. VRC01-class bnAbs that target the CD4 binding site (CD4bs) of trimeric HIV-1 envelope (Env) glycoprotein spikes are particularly attractive to elicit because of their extraordinary breadth and potency...

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Bibliographic Details
Main Authors: Celia C LaBranche, Andrew T McGuire, Matthew D Gray, Shay Behrens, Peter D Kwong, Xuejun Chen, Tongqing Zhou, Quentin J Sattentau, James Peacock, Amanda Eaton, Kelli Greene, Hongmei Gao, Haili Tang, Lautaro G Perez, Kevin O Saunders, John R Mascola, Barton F Haynes, Leonidas Stamatatos, David C Montefiori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6237427?pdf=render

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http://europepmc.org/articles/PMC6237427?pdf=render

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