The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs

The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs

GPR88 is an orphan G protein-coupled receptor (GPCR) considered as a promising therapeutic target for neuropsychiatric disorders; its pharmacology, however, remains scarcely understood. Based on our previous report of increased delta opioid receptor activity in Gpr88 null mice, we investigated the i...

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Bibliographic Details
Main Authors: Thibaut Laboute, Jorge Gandía, Lucie P Pellissier, Yannick Corde, Florian Rebeillard, Maria Gallo, Christophe Gauthier, Audrey Léauté, Jorge Diaz, Anne Poupon, Brigitte L Kieffer, Julie Le Merrer, Jérôme AJ Becker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
in vitro pharmacology
BRET experiments
beta-arrestin
GPCR oligomerisation
knockout animals
in vivo pharmacology
Online Access:https://elifesciences.org/articles/50519

Internet

https://elifesciences.org/articles/50519

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