Treatment of voluminous and complicated superficial slow-flow vascular malformations with sirolimus (PERFORMUS): protocol for a multicenter phase 2 trial with a randomized observational-phase design

Treatment of voluminous and complicated superficial slow-flow vascular malformations with sirolimus (PERFORMUS): protocol for a multicenter phase 2 trial with a randomized observational-phase design

Abstract Background Slow-flow superficial vascular malformations (VMs) are rare congenital anomalies that can be responsible for pain and functional impairment. Currently, we have no guidelines for their management, which can involve physical bandages, sclerotherapy, surgery, anti-inflammatory or an...

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Main Authors: Annabel Maruani, Olivia Boccara, Didier Bessis, Laurent Guibaud, Pierre Vabres, Juliette Mazereeuw-Hautier, Sébastien Barbarot, Christine Chiaverini, Sophie Blaise, Catherine Droitcourt, Stéphanie Mallet, Ludovic Martin, Gérard Lorette, Jean-Baptiste Woillard, Annie-Pierre Jonville-Bera, Jérome Rollin, Yves Gruel, Denis Herbreteau, Dominique Goga, Anne le Touze, Sophie Leducq, Valérie Gissot, Baptiste Morel, Elsa Tavernier, Bruno Giraudeau, Groupe de Recherche de la Societé Française de Dermatologie Pédiatrique
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Trials
Subjects:
Vascular anomalies
Lymphatic malformations
Venous malformations
Children
Sirolimus
Mammalian target of rapamycin inhibitors
Online Access:http://link.springer.com/article/10.1186/s13063-018-2725-1

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http://link.springer.com/article/10.1186/s13063-018-2725-1

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