Receptor-Activator of Nuclear KappaB Ligand Expression as a New Therapeutic Target in Primary Bone Tumors.

Receptor-Activator of Nuclear KappaB Ligand Expression as a New Therapeutic Target in Primary Bone Tumors.

The receptor-activator of nuclear kappaB ligand (RANKL) signaling pathway plays an important role in the regulation of bone growth and mediates the formation and activation of osteoclasts. Osteoclasts are involved in significant bone resorption and destruction. Denosumab is a fully human monoclonal...

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Bibliographic Details
Main Authors: Tetsuro Yamagishi, Hiroyuki Kawashima, Akira Ogose, Takashi Ariizumi, Taro Sasaki, Hiroshi Hatano, Tetsuo Hotta, Naoto Endo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4862691?pdf=render

Internet

http://europepmc.org/articles/PMC4862691?pdf=render

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