Mapping the genetic architecture of gene expression in human liver.

Mapping the genetic architecture of gene expression in human liver.

Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order disease traits. Therefore, identifying the molecular phenotypes that vary in response to changes in DNA a...

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Bibliographic Details
Main Authors: Eric E Schadt, Cliona Molony, Eugene Chudin, Ke Hao, Xia Yang, Pek Y Lum, Andrew Kasarskis, Bin Zhang, Susanna Wang, Christine Suver, Jun Zhu, Joshua Millstein, Solveig Sieberts, John Lamb, Debraj GuhaThakurta, Jonathan Derry, John D Storey, Iliana Avila-Campillo, Mark J Kruger, Jason M Johnson, Carol A Rohl, Atila van Nas, Margarete Mehrabian, Thomas A Drake, Aldons J Lusis, Ryan C Smith, F Peter Guengerich, Stephen C Strom, Erin Schuetz, Thomas H Rushmore, Roger Ulrich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2365981?pdf=render

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http://europepmc.org/articles/PMC2365981?pdf=render

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