Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke

Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke

The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2+]i) rise, which are not only important for regulating cell function but their deregulation can also lead to cell damage. R...

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Bibliographic Details
Main Authors: Jaepyo Jeon, Fan Bu, Guanghua Sun, Jin-Bin Tian, Shun-Ming Ting, Jun Li, Jaroslaw Aronowski, Lutz Birnbaumer, Marc Freichel, Michael X. Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
neurological disease
TRPC4 knockout
calcium
neuroprotection
neurodegeneration
neuronal death
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.618663/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.618663/full

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