A Fibrinogen Alpha Fragment Mitigates Chemotherapy-Induced MLL Rearrangements

A Fibrinogen Alpha Fragment Mitigates Chemotherapy-Induced MLL Rearrangements

Rearrangements in the Mixed Lineage Leukemia breakpoint cluster region (MLLbcr) are frequently involved in therapy-induced leukemia, a severe side effect of anti-cancer therapies. Previous work unraveled Endonuclease G as the critical nuclease causing initial breakage in the MLLbcr in response to di...

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Bibliographic Details
Main Authors: Julia Eberle, Rahel Stefanie Wiehe, Boris Gole, Liska Jule Mattis, Anja Palmer, Ludger Ständker, Wolf-Georg Forssmann, Jan Münch, J. Christof M. Gebhardt, Lisa Wiesmüller
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
bioactive peptide
doxorubicin
Endonuclease G
hematopoietic stem and progenitor cells
inflammatory signaling
mixed lineage leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.689063/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.689063/full

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