Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and identify DECR1, encoding the rate-limiting enzyme...

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Bibliographic Details
Main Authors: Zeyad D Nassar, Chui Yan Mah, Jonas Dehairs, Ingrid JG Burvenich, Swati Irani, Margaret M Centenera, Madison Helm, Raj K Shrestha, Max Moldovan, Anthony S Don, Jeff Holst, Andrew M Scott, Lisa G Horvath, David J Lynn, Luke A Selth, Andrew J Hoy, Johannes V Swinnen, Lisa M Butler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
lipid metabolism
prostate cancer
ferroptosis
androgen
Online Access:https://elifesciences.org/articles/54166

Internet

https://elifesciences.org/articles/54166

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