A phased SNP-based classification of sickle cell anemia HBB haplotypes

A phased SNP-based classification of sickle cell anemia HBB haplotypes

Abstract Background Sickle cell anemia causes severe complications and premature death. Five common β-globin gene cluster haplotypes are each associated with characteristic fetal hemoglobin (HbF) levels. As HbF is the major modulator of disease severity, classifying patients according to haplotype i...

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Bibliographic Details
Main Authors: Elmutaz M. Shaikho, John J. Farrell, Abdulrahman Alsultan, Hatem Qutub, Amein K. Al-Ali, Maria Stella Figueiredo, David H.K. Chui, Lindsay A. Farrer, George J. Murphy, Gustavo Mostoslavsky, Paola Sebastiani, Martin H. Steinberg
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Genomics
Subjects:
SNPs
Sickle cell
Haplotype classification
Online Access:http://link.springer.com/article/10.1186/s12864-017-4013-y

Internet

http://link.springer.com/article/10.1186/s12864-017-4013-y

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