Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB.

Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB.

BACKGROUND: Reduced chemosensitivity of solid cancer cells represents a pivotal obstacle in clinical oncology. Hence, the molecular characterization of pathways regulating chemosensitivity is a central prerequisite to improve cancer therapy. The hypoxia-inducible factor HIF-1alpha has been linked to...

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Bibliographic Details
Main Authors: Nadine Rohwer, Christof Dame, Anja Haugstetter, Bertram Wiedenmann, Katharina Detjen, Clemens A Schmitt, Thorsten Cramer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2919384?pdf=render

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http://europepmc.org/articles/PMC2919384?pdf=render

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