Implications of alpha-synuclein nitration at tyrosine 39 in methamphetamine-induced neurotoxicity in vitro and in vivo

Implications of alpha-synuclein nitration at tyrosine 39 in methamphetamine-induced neurotoxicity in vitro and in vivo

Methamphetamine is an amphetamine-type psychostimulant that can damage dopaminergic neurons and cause characteristic pathological changes similar to neurodegenerative diseases such as Parkinson’s disease. However, its specific mechanism of action is still unclear. In the present study, we establishe...

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Bibliographic Details
Main Authors: Hong-Hua Qiao, Lin-Nan Zhu, Yue Wang, Jia-Liang Hui, Wei-Bing Xie, Chao Liu, Ling Chen, Ping-Ming Qiu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; alpha-synuclein; nitrated α-synuclein; Parkinson′s disease; methamphetamine; N-nitro-L-arginine; alpha-synuclein aggregation; apoptosis; neurotoxicity; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=2;spage=319;epage=327;aulast=Qiao

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=2;spage=319;epage=327;aulast=Qiao

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