Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition.

Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition.

The actin capping protein (CP) tightly binds to the barbed end of actin filaments, thus playing a key role in actin-based lamellipodial dynamics. V-1 and CARMIL proteins directly bind to CP and inhibit the filament capping activity of CP. V-1 completely inhibits CP from interacting with the barbed e...

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Main Authors: Shuichi Takeda, Shiho Minakata, Ryotaro Koike, Ichiro Kawahata, Akihiro Narita, Masashi Kitazawa, Motonori Ota, Tohru Yamakuni, Yuichiro Maéda, Yasushi Nitanai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20625546/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20625546/pdf/?tool=EBI

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