MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation
Abstract Background Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of the genome. Although increasing evidence supports a regulatory role for...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-05-01
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Series: | Epigenetics & Chromatin |
Online Access: | https://doi.org/10.1186/s13072-021-00398-4 |