MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation

MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation

Abstract Background Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of the genome. Although increasing evidence supports a regulatory role for...

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Bibliographic Details
Main Authors: Judd C. Rice, Benjamin H. Weekley, Tomas Kanholm, Zhihui Chen, Sunyoung Lee, Daniel J. Fernandez, Rachel Abrahamson, Alessandra Castaldi, Zea Borok, Brian D. Dynlacht, Woojin An
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Epigenetics & Chromatin
Online Access:https://doi.org/10.1186/s13072-021-00398-4

Internet

https://doi.org/10.1186/s13072-021-00398-4

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