Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo

Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo

Macrophages are heterogeneous leukocytes regulated in a tissue- and disease-specific context. While in vitro macrophage models have been used to study diseases empirically, a systematic analysis of the transcriptome thereof is lacking. Here, we acquired gene expression data from eight commonly-used...

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Bibliographic Details
Main Authors: Hung-Jen Chen, Andrew Y. F. Li Yim, Guillermo R. Griffith, Wouter J. de Jonge, Marcel M. A. M. Mannens, Enrico Ferrero, Peter Henneman, Menno P. J. de Winther
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
meta-analysis
elastic net classification
macrophages
alveolar macrophages (AMs)
synovial macrophages (SMs)
adipose tissue macrophages (ATMs)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02887/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02887/full

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