α-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway.

α-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway.

The present study investigates the effects and mechanisms of α-Lipoic acid (LA) on myocardial infarct size, cardiac function and cardiomyocyte apoptosis in rat hearts subjected to in vivo myocardial ischemia/reperfusion (MI/R) injury.Male adult rats underwent 30 minutes of ischemia followed by 3, 24...

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Bibliographic Details
Main Authors: Chao Deng, Zhongchan Sun, Guang Tong, Wei Yi, Li Ma, Bijun Zhao, Liang Cheng, Jinzhou Zhang, Feng Cao, Dinghua Yi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3591314?pdf=render

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http://europepmc.org/articles/PMC3591314?pdf=render

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