Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages

Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages

ABCA1 exports excess cholesterol from cells to apoA-I and is essential for HDL synthesis. Genetic studies have shown that ABCA1 protects against cardiovascular disease. We have previously shown that the interaction of apoA-I with ABCA1 activates signaling molecule Janus kinase 2 (JAK2), which optimi...

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Bibliographic Details
Main Authors: Chongren Tang, Barbara A. Houston, Carl Storey, Renee C. LeBoeuf
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Journal of Lipid Research
Subjects:
inflammation
high density lipoprotein
apolipoprotein A-I
ATP binding cassette transporter A1
signal transducer and activator of transcription 3
suppressor of cytokine signaling 3
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309871

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http://www.sciencedirect.com/science/article/pii/S0022227520309871

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